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Department of Medicine and the Sylvester Comprehensive Cancer Center Postdoctoral Positions in the Department of Medicine and the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are available to study: 1) innate immune mechanisms associated with host defense against viral and malignant disease, or 2) Viral oncolysis using murine tumor models. Appropriate qualifications with experience in tumor immunology and/or molecular biology is required. Interested individuals should send their resumes to: Gina Scott, Administrative Assistant to Dr. Glen N. Barber, Department of Medicine, Sylvester Comprehensive Cancer Center, Rm 511, Papanicolaou Building, 1550 NW 10th Ave [M710], University of Miami Miller School of Medicine, Miami, FL 33136. Tel:(305)243-9492, Fax: (305)243-5885, Email: Gscott2@med.miami.edu. Posted: February 5, 2007 Postdoctoral position in RNA therapeutics: Aptamers & siRNA The Dodson Interdisciplinary Immunotherapy Institute at Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine seeks a postdoctoral fellow for its cancer immunotherapy program to develop aptamer and siRNA-based technologies in the setting of cancer immunotherapy. Extensive experience in molecular biology techniques working with RNA and proteins is mandatory. Please submit a curriculum vitae to Eli Gilboa at dmii@med.miami.edu Posted: February 5, 2007 Postdoctoral position in cancer immunotherapy: Induction of CD4 T cell immunity by class II retargeting The Dodson Interdisciplinary Immunotherapy Institute at Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine seeks a postdoctoral fellow for its cancer immunotherapy program to promote the induction of CD4 T cell responses in the setting of tumor immunity using preclinical murine tumor models by developing methods to redirect endogenously expressed nucleic acid-encoded antigens into the class II presentation pathway. Experience in cellular biology and immunology is mandatory and experience in subcellular trafficking is desirable. Please submit a curriculum vitae to Eli Gilboa at dmii@med.miami.edu Posted: February 5, 2007 Postdoctoral position in cancer immunotherapy: Modulating costimulation with aptamers The Dodson Interdisciplinary Immunotherapy Institute at Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine seeks a postdoctoral fellow for its cancer immunotherapy program to develop new methods of potentiating antitumor immunity using preclinical murine tumor models by manipulating costimulation using aptamers and aptamer-targeted siRNA. Experience in cellular immunology is mandatory and experience using small animal models and/or molecular biology is desirable. Please submit a curriculum vitae to Eli Gilboa at dmii@med.miami.edu Posted: February 5, 2007 Postdoctoral position in cancer immunotherapy: Overcoming tumor-induced immune suppression The Dodson Interdisciplinary Immunotherapy Institute at Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine seeks a postdoctoral fellow for its cancer immunotherapy program to develop methods to overcome tumor-induced immune suppression using novel strategies based on aptamers and aptamer-guided siRNA. Experience in cellular immunology is mandatory and experience using small animal models and/or molecular biology is desirable. Please submit a curriculum vitae to Eli Gilboa at dmii@med.miami.edu Posted: February 5, 2007 Postdoctoral position in autoimmunity & transplantation: Tolerance induction with aptamer-targeted siRNA The Dodson Interdisciplinary Immunotherapy Institute and the Diabetes Research Institute of  University of Miami Miller School of Medicine seeks a postdoctoral fellow for its autoimmunity & transplantation programs to develop methods for the selective elimination of activated autoreactive T lymphocytes in pre-clinical murine models of GVHD, autoimmunity and allotransplantation rejection, using novel reagents based on aptamer-siRNA chimaeras and new methods to induce T cell tolerance. Experience in cellular immunology is mandatory and experience using small animal models and/or molecular biology is desirable. Please submit a curriculum vitae to Eli Gilboa at dmii@med.miami.edu Posted: February 5, 2007 Post-doctoral Training Positions Available in Translational Breast Cancer Research The Braman Family Breast Cancer Institute at Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine seeks postdoctoral candidates for its T32 translational breast cancer research training. The program focuses on the molecular biology of breast cancer and experimental therapeutics. Candidates must have a Ph.D and/or M.D with not more than 4 years of post MD or PhD training to be eligible. All candidates must be US citizens or permanent residents of the United States to apply. Prior expertise in molecular/cellular biology is preferred. This translational postdoctoral program will provide exposure to expertise in many aspects of multidisciplinary breast cancer research. Please submit a curriculum vitae and three letters of reference to: Joyce Slingerland MD FRC(C) PhD Email: jslingerland@med.miami.edu Tel: 305-243-6788 Posted October 25, 2007 Postdoctoral Position Available EXTRAORDINARY OPPORTUNITY NIH funded Research opportunities are currently available to study the cellular mechanisms that preserve totipotency or pluripotency in cells. Model system: Primordial germ cells (PGCs), precursors to the gametes, are prime exemplars of totipotency as they retain full developmental potential. We study how totipotency is preserved in PGCs during frog development. A key question is: “How are PGCs in Xenopus prevented from becoming somatic endoderm when all the cells around them take on that fate?” • Based on our previous data, we know that loss of Xnos1 gene activity in PGCs results in a loss of the primordial germ cell lineage. • We know Xnos1 is a potent repressor of gene expression • We know human nos1 is highly expressed in breast cancer cell lines. We want to know: • What are the genetic targets of Xnos1 repression? • How does repression result in totipotency? • What is the mechanism of Xnos1 repression? Successful candidate will: • Have excellent molecular cloning and biochemistry skills • Be curious, hardworking, ambitious, organized and a team player • Have experience with immunological techniques: western blotting, protein production, IP • Enjoy teaching others • Not be afraid of frogs! Love developmental biology! This is an extraordinary opportunity for someone. The molecular mutants are in hand. Progress on these problems will be rapid. Results from these studies will have wide impact and thus they have excellent potential for publication in outstanding journals. Applicants please provide a CV and references to: Mary Lou King, Ph.D. Professor of Cell Biology Dept. of Cell Biology and Anatomy University of Miami, Miller School of Medicine 1600 N.W. 10th Ave (R-124) Miami, Florida 33136 mking@med.miami.edu Phone: 305-243-5643 Posted October 19, 2007 Postdoctoral Position Description: A postdoctoral position is available immediately at the University of Miami Miller School of Medicine Dept. of Molecular and Cellular Pharmacology for an outstanding candidate interested in androgen receptor and oncogenic signaling in prostate cancer. Qualified candidates with a Ph.D. or M.D. degree, 0-2 years of previous post-doctoral experience and a strong publication record are encouraged to apply. Experience with mouse xenograft models of cancer, tissue culture, molecular biology, cell biology and microscopic cell imaging is desirable. Please submit curriculum vitae, brief statement of research experience and interests, and the names of three references to: Kerry Burnstein, Ph.D. Posted August 9, 2007 Postdoctoral Position Postdoctoral position to study the biophysics and physiology of electrogenic membrane proteins. The lab is focused on the molecular function of glucose sensors and their effects on physiology. Current projects use a variety of techniques: cloning and expression of proteins, electrophysiology, voltage-clamp fluorometry (e.g., Diez-Sampedro et al., '04 Biochem; Diez-Sampedro et al., '03 PNAS). Send CV and references to Dr. Ana Diez-Sampedro Dept. of Physiology and Biophysics Univ. of Miami School of Med. P.O. Box 016430 Miami, FL 33101 or by email adiezsampedro@med.miami.edu Posted August 9, 2007 Postdoctoral Research Position Postdoctoral research position available to investigate receptor-G protein regulation of phospholipase C signaling in vitro and in cultured cells. Our laboratory has shown that phospholipase C is regulated by the signaling phospholipid, phosphatidic acid through interaction within a defined binding region (Ross et al J Biol Chem 281, 33087-33094, 2006). We wish to further delineate the binding determinants for phosphatidic acid and generate point mutations, which will be used for mechanistic studies. The successful candidate will have research experience in molecular biology, biochemistry and cell culture, and familiarity in signal transduction research. Expertise in primer design, site directed mutagenesis, protein expression using bacterial vectors and protein purification is required. Interested applicants should send their CV and e-mail address of 3 references to ilitosch@med.miami.edu. Posted August 9, 2007 Postdoctoral Associate in Sensory Neurobiology Program in Neuroscience and Department of Physiology, University of Miami Miller School of Medicine I have an opening for a qualified individual who is interested in sensory neurobiology, particularly the chemical senses (taste and smell). My laboratory uses a multidisciplinary approach to study chemosensory transduction, synaptic transmission, and signal processing in mammalian taste buds (e.g. cf. Huang et al, 2007, PNAS 104:6436-41. Applicants should have an MD, PhD, or DVM with research training in physiology, neuroscience, genetics, cell biology or a related field. Experience with functional imaging (calcium imaging, voltage imaging in tissues or cell cultures) is highly desirable. Motivated and enthusiastic individuals are encouraged to apply. Please email a CV, a brief description of your accomplishments and goals, and contact information for 3 to 4 references to: Prof. Stephen Roper. I will hold this position open until it is filled. Posted August 6, 2007 Postdoctoral Position Available The postdoctoral associate will be a part of the Cardiac Signal Transduction and Cellular Biology Laboratory and participate in current research which asks how the formation of multimolecular protein complexes confers specificity in intracellular signaling. A major focus of the lab has been the mAKAP signalosome that facilitates crosstalk between cAMP, calcium and MAP-kinase signaling pathways and that is important for the induction of myocyte hypertrophy. Other interests include the identification of novel scaffolds for the phosphatase calcineurin. A wide range of techniques are being used to address these questions including the biochemical analysis of recombinant proteins in vitro, transfection of primary cardiac myocyte cultures, live cell imaging and the generation of mutant mice models. Candidates will be required to get involved in the experiments and gather data. Minimum qualifications include a Ph.D. or equivalent. Enthusiastic individuals with experience in molecular biology, biochemistry, cell biology or cardiac physiology are encouraged to apply. Candidates with two to three years of experience preferred. An appropriate combination of relevant education, experience and/or certifications will be considered. Michael S. Kapiloff, M.D., Ph.D. Associate Professor, Departments of Medicine and Pediatrics Director,  Cardiac Signal Transduction and Cellular Biology Laboratory University of Miami Miller School of Medicine Phone: 305-243-7863 (office) 305-243-7864 (lab) 305-243-3906 (fax) Posted July 18, 2007 Postdoctoral Position Available The D’Urso laboratory is seeking a post-doctoral research scientist to assist in studies on systems biology of complex human disease. The study will involve identifying genes in model organisms that are homologous to human disease related genes. Once candidate genes are identified, hi-throughput synthetic genetic analysis (SGA) will be conducted in yeast to identify potential functions for these genes (where no function is known) or to address the topology of the interacting gene network. Experience in genetics would be helpful but not essential. Please contact Dr. Gennaro D’Urso directly at either 305-243-3105 or email at gdurso@miami.edu. Posted July 11, 2007 Postdoctoral Position, Cardiac Signal Transduction and Cellular Biology Laboratory The postdoctoral associate will be a part of the Cardiac Signal Transduction and Cellular Biology Laboratory and participate in current research which asks how the formation of multimolecular protein complexes confers specificity in intracellular signaling. A major focus of the lab has been the mAKAP signalosome that facilitates crosstalk between cAMP, calcium and MAP-kinase signaling pathways and that is important for the induction of myocyte hypertrophy. Other interests include the identification of novel scaffolds for the phosphatase calcineurin. A wide range of techniques are being used to address these questions including the biochemical analysis of recombinant proteins in vitro, transfection of primary cardiac myocyte cultures, live cell imaging and the generation of mutant mice models. Candidates will be required to get involved in the experiments and gather data. Minimum qualifications include a Ph.D. or equivalent. Enthusiastic individuals with experience in molecular biology, biochemistry, cell biology or cardiac physiology are encouraged to apply. Candidates with two to three years of experience preferred. An appropriate combination of relevant education, experience and/or certifications will be considered. Contact Dr. Michael Kapiloff kapiloff@ohsu.edu or apply on-line at www.careers.med.miami.edu. Posted June 6, 2007 Postdoctoral Positions funded by the National Heart, Lung, and Blood Institute The Department of Molecular and Cellular Pharmacology currently has two postdoctoral positions funded by the National Heart, Lung, and Blood Institute. Research can be conducted in the lab of one of the training grant faculty members in Pharmacology, Medicine, Cardiology or Cell Biology. Interested applicants must hold a Ph.D. or M.D. and must be a US citizen or Permanent Resident.  For further information, contact: James Potter, Ph.D., Professor and Chairman of the Department of Molecular and Cellular Pharmacology, at 305-243-5874 or jdpotter@miami.edu. Posted May 29, 2007 Department of Molecular and Cellular Pharmacology University of Miami Miller School of Medicine A Postdoctoral position is available in a cardiac development laboratory in the Department of Molecular and Cellular Pharmacology at The Miller School of Medicine. Our lab focuses on the molecular and cellular mechanisms of heart valve development and adult disease using in vitro and in vivo assays. Research activities in our lab include PCR analysis, gene cloning, immunohistochemistry, in situ hybridization, tissue culture (transfections, primary cell culture) and animal model systems. Applicants must hold a Ph.D/MD with good English communication skills. For consideration, please send a recent CV along with the names of three references to jlincoln@med.miami.edu. Further information on our work can be found at http://chroma.med.miami.edu/pharm/faculty_Lincoln.html. Posted: Mar 12, 2007 Department of Physiology University of Miami Miller School of Medicine Postdoctoral position to study ion channels involved in touch perception and neurodegeneration Our laboratory uses genetic, molecular, behavioral, electrophysiological and imaging approaches to study the role of ion channels in sensory perception and neuronal death in Caenorhabditis elegans and mammalian systems. Applicant should have a PhD in physiology, neuroscience, genetics, cell biology or related fields. Experience using C. elegans as a model organism is a plus. Highly motivated and enthusiastic individuals are encouraged to apply. Please email a CV, a brief description of accomplishments and goals, and contact information for 3 references to: Laura Bianchi. The position will be open until filled. Posted: Nov 1, 2006 Department of Ophthalmology University of Miami Miller School of Medicine A Postdoctoral position is available immediately in the Department of Ophthalmology McKnight Vision Research Center. The candidate will join an on-going project to identify antigens as disease biomarkers. The candidate will also participate in other related research projects to discover and characterize novel protein targets by phage display technology. Previous trainings and laboratory experience in molecular biology and cell biology are preferred. The research activities for the selected candidate will include phage library screening, various assays for antigen-antibody interaction, PCR, subcloning, recombinant protein expression and purification, functional characterization, etc. The candidate must have a Ph.D. degree with the ability to work independently and good English communication skills (both verbal and written). Please contact Dr. Wei Li at wli@med.miami.edu. Posted: Oct 13, 2006 Department of Microbiology and Immunology University of Miami Miller School of Medicine Postdoctoral positions are immediately available in the laboratory of Dr. Eckhard R. Podack. Applicants with animal handling and/or tumor immunology experience are preferred. For examples of recent studies please refer to the following website: http://chroma.med.miami.edu/micro/faculty_podack.html Applicants should email a CV to following address or call for an appointment and details: epodack@miami.edu. Posted: July 25 2006 Department of Microbiology and Immunology University of Miami Miller School of Medicine Postdoctoral Positions in the Department of Microbiology and Immunology and Sylvester Cancer Center at the University of Miami School of Medicine are available to study innate immune responses to viral and malignant disease. These positions require a Ph.D. and experience in VIROLOGY, IMMUNOLOGY and/or vaccine development and evaluation. Projects involve developing novel oncolytic viruses for the treatment of malignant disease and nanoparticle based strategies for the prevention and treatment of pathogen-associated disease. Appropriate qualifications, experience in virology, immunology, working with mice or molecular biology is required. For consideration, please send curriculum vitae to Dr. Glen N. Barber, gbarber@med.miami.edu. Posted: December 12, 2005 Department of Microbiology and Immunology University of Miami Miller School of Medicine An NIH/NCI funded postdoctoral position is available immediately using a new animal and cell model to investigate molecular mechanisms of carcinogenesis and angiogenesis activation by the Kaposi's sarcoma herpesvirus (KSHV). Applicants should have a Ph.D. or M.D./Ph.D., good publications in a relevant field, and experience with molecular and cellular biology techniques. Expertise with BAC's, mouse tumors or gene arrays is a plus. Interested individuals should email their C.V. and send to letters of recommendation to: Dr. Enrique Mesri, Viral Oncology Research Program, Department of Microbiology and Immunology and the Sylvester Comprehensive Cancer Center, 1550 NW 10th Avenue, Papanicolaou Building 109B (R138), Miami, Florida 33136. Email: emesri@med.miami.edu. Phone: 305-243-5659. FAX: 305-243-8309. Posted: October 3, 2005 Department of Microbiology and Immunology University of Miami Miller School of Medicine A Postdoctoral Associate position is available to study dendritic cell differentiation at the Sylvester Comprehensive Cancer Center/University of Miami. Selected candidates will work on the molecular basis of dendritic cell differentiation, specifically on specific signal transduction pathways and downstream gene regulation. M.D. or Ph.D. in biological sciences is required. Experience in molecular biology or cellular immunology is required. Salary and benefits are competitive. Interested individuals should email their C.V. including addresses of 3 referees to: Kelvin Lee, M.D., Professor of Microbiology and Immunology, Department of Microbiology and Immunology and The Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136. Email: klee@med.miami.edu and cc to duptgrow@miami.edu. Posted: September 29, 2005 Department of Ophthalmology University of Miami Miller School of Medicine A Postdoctoral Fellow position is available in a molecular biology laboratory in the Department of Ophthalmology and Bascom Palmer Eye Institute, University of Miami Miller School of Medicine. Research areas: molecular biology, gene therapy, stem cells and immunology. Eligible candidate will engage in the study of ocular gene therapy, stem cell research, molecular ophthalmology and ocular immune disorders. Previous laboratory experience in molecular biology, cell biology, protein biochemistry, immunology or related skills required. Applicants with a Ph.D. And/or M.D. with documented research experience in these areas are welcome to apply. The applicant must demonstrate excellent oral and written communication skills. Salary: competitive. Please send a letter of interest including your career goals, curriculum vitae and three letters of recommendation to Wei Li, Ph.D. at wli@med.miami.edu Posted: September 13, 2005 Laboratories for Airway Biology Department of Medicine University of Miami Miller School of Medicine Molecular and cellular aspects of normal and diseased states of the airways. Ciliary motion, ion transport, proteases, and glycosaminoglycans. Techniques include live cell imaging using fluorescence and confocal microscopes, cell biology, biochemistry and computational analysis. More information... Posted: August 9, 2005 Department of Ophthalmology University of Miami Miller School of Medicine Position is available to study the cellular and molecular mechanisms of neurite growth and patterning during development and after injury. The focus is on intrinsic and extrinsic mediators of axon and dendrite growth in vitro and in vivo, using rodent model systems, with ample opportunity to expand in a number of directions (Science 296: 1860-4; Genes Dev 17:941-58). Individual will work directly with Dr. Jeffrey Goldberg in the fast-growing McKnight Vision Research Center of the Bascom Palmer Eye Institute. Ph.D. or M.D. degree required. Applicants should be able to demonstrate a strong background in molecular, cellular or developmental neuroscience. A CV with record of publications or journal submission and 2 references’ names required. Please e-mail to: jgoldberg@med.miami.edu. Posted: March 14, 2005 Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine A postdoctoral research fellow position is available in the Cutaneous Biology Research Laboratory in the Department of Dermatology and Cutaneous Surgery. The position is to study cellular & molecular biology of cutaneous wound healing and skin tumors. The study is involved in the laminin-integrin signaling pathway in epithelial/endothelial basement membrane extracellular matrix. Self-motivated candidates with experience in cellular and molecular biology, biochemistry, genetics or animal models is desirable. A PhD, MD/PhD or MD degree is required. Salary will be determined commensurate with the candidate's experience. Please send curriculum vitae and three names of references to Dr. Jie Li at jli@med.miami.edu Posted: March 14, 2005 Department of Orthopaedic Research University of Miami Miller School of Medicine Applications are invited for a postdoctoral position starting fourth quarter, 2004. Applicants should have a M.D. and/or Ph.D. degree. Our laboratory investigates biochemical/molecular mechanisms of chondrosarcoma metastasis and extracellular matrix remodeling. A strong background in molecular/cellular biology, and fluency in English are mandatory. Experience developing animal tumor models is desirable. We are seeking candidates who are self-motivated and career-oriented. Salary will be determined commensurate with the candidate's experience and includes an attractive benefit package. The University of Miami was rated the second best institution worldwide for postdoctoral fellows, in a survey conducted by The Scientist. However, we are unable to sponsor H1 VISAs for postdoctoral positions at this time. Interested, qualified applicants should send a current curriculum vitae, bibliography, summary of past accomplishments, and three letters of recommendation to: Dr. Sean P. Scully University of Miami Miller School of Medicine Department of Orthopaedics and Rehabilitation (D-27) Cedar's Medical Center, East Building, 4th Floor P.O. Box 016960 1400 N.W. 12th Ave Miami, FL 33136 or via email: SScully@med.miami.edu. Posted: March 14, 2005 top