Positions Available
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Research Instructor/Assistant Professor
The Chairman, Dr. James D. Potter, of the Department of Molecular and Cellular Pharmacology at the University of Miami School of Medicine is seeking applications for a Research Instructor/ Assistant Professor position. This individual will work closely with Dr. Potter and will be involved in all of his ongoing research projects including experimental design, data analysis and interpretation, the preparation of manuscripts for publication and the development of grant applications. This position will also be responsible for the day-to-day operation of the lab, monitoring the daily activities and progress. Other duties include, but are not limited to, the supervision of lab personnel, including technicians and graduate students.
The major theme of the lab’s research projects is the study of the cellular signaling events associated with the regulation of cardiac and skeletal muscle contraction normal and pathological states. Current areas of interest are:
- Mechanism of Cardiac Muscle Regulation by Troponin – the investigation of the Ca2+ regulation of cardiac muscle contraction by cardiac troponin (CTn) as well as the structure and function of the various domains of two of the subunits of CTn, troponin I (CTnI) and troponin T (CTnT) in the regulation of cardiac muscle contraction is being pursued in the lab.
- Familial Hypertrophic Cardiomyopathy (FHC) - To date, numerous mutations have been found in cardiac myosin heavy chains, a-tropomyosin, actin, titin, protein C, troponin T (TnT) and troponin I (TnI) that are associated with this condition. The experiments being performed (in vitro and transgenic models) are designed to determine the mechanisms by which these occur.
- Ca2+ Regulation of Skeletal Muscle Contraction - Previous studies have suggested that the primary role for troponin T(TnT) is to interact with and anchor the complex of troponin I (TnI) and troponin C (TnC) to the thin filaments through TnT's interaction with tropomyosin (Tm). Recent results from Dr. Potter’s lab suggest that in addition to this role, TnT may have two additional functions that have important physiological consequences. These additional functions of TnT are currently being investigated in skeletal muscle.
- Physiological Role of the Myosin Regulatory Light Chains - The long-term goals of these studies are to determine the physiological role(s) of the regulatory light chains of myosin (RLC) in skeletal and cardiac muscle contraction. The central hypothesis being tested is that Ca2+ and/or Mg2+ binding to the RLC and their phosphorylation by myosin light chain kinase (MLCK), play key roles in the regulation and/or modulation of contraction.
- Structural Studies of EF-Hand Ca2+ Binding Proteins - The major goal of this project is to determine the structural factors which affect the Calcium affinity and metal ion specificity of the Calcium binding sites found in the "EF-hand" family of proteins.
The ideal candidate will have a Ph.D. with experience in Biochemistry, Biophysics or Molecular Biology. Two or more years of Postdoctoral training is preferred. Qualified applicants should send electronic copies of their curriculum vitae, description of current and future research interests, and the names and addresses of three references to: Dr. James D. Potter, Chairman, Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, P.O. Box 016189, Miami, Fl 33101. http://chroma.med.miami.edu/pharm/faculty_JPotter.html Email address: elalor@med.miami.edu. The University of Miami is an Equal Opportunity/Affirmative Action Employer.
Posted: March 16, 2004
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Postdocs
Postdoctoral Position in the Contractile Proteins Laboratory
A Postdoctoral position is available in the laboratory of Dr. Danuta Szczesna-Cordary (webpage) in the Department of Molecular and Cellular Pharmacology at The Miller School of Medicine.
Our lab focuses on the Ca2+ regulation of striated (skeletal and cardiac) muscle contraction. In particular, we study the role of the myosin regulatory (RLC) and essential (ELC) light chains in the Ca2+ dependent force generation and the kinetics of myosin cross-bridges. Most recently, our research addresses the mechanisms by which mutations in RLC and ELC cause familial hypertrophic cardiomyopathy (FHC) and lead to sudden cardiac death.
Interested applicants should send their CV with three references to: dszczesna@med.miami.edu.
Posted August 24, 2007
Postdoctoral Positions funded by the National Heart, Lung, and Blood Institute
The Department of Molecular and Cellular Pharmacology currently has two postdoctoral positions funded by the National Heart, Lung, and Blood Institute. Research can be conducted in the lab of one of the training grant faculty members in Pharmacology, Medicine, Cardiology or Cell Biology.
Interested applicants must hold a Ph.D. or M.D. and must be a US citizen or Permanent Resident. For further information, contact: James Potter, Ph.D., Professor and Chairman of the Department of Molecular and Cellular Pharmacology, at 305-243-5874 or jdpotter@miami.edu.
Postdoctoral Position in a Cardiac Development Laboratory
A Postdoctoral position is available in a cardiac development laboratory in the Department of Molecular and Cellular Pharmacology at The Miller School of Medicine.
Our lab focuses on the molecular and cellular mechanisms of heart valve development and adult disease using in vitro and in vivo assays. Research activities in our lab include PCR analysis, gene cloning, immunohistochemistry, in situ hybridization, tissue culture (transfections, primary cell culture) and animal model systems.
Applicants must hold a Ph.D/MD with good English communication skills. For consideration, please send a recent CV along with the names of three references to jlincoln@med.miami.edu. Further information on our work can be found at http://chroma.med.miami.edu/pharm/faculty_Lincoln.html.
Posted: March 12, 2007
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Postdoctoral Fellow in Membrane Traffic and Cell Signaling.
A NIH funded postdoctoral position is available to study regulation of membrane dynamics using the powerful yeast model system, Saccharomyces cerevisiae. Particular interests include the role of phosphorylation and the actin cytoskeleton in endocytosis and the function of clathrin in endocytosis and sorting to the lysosome/vacuole. Recent studies have analyzed endocytosis by live cell imaging. Other projects include studies of the function of 14-3-3 proteins and type one protein phosphatase. An opportunity to perform chemical genomic screens to identify small molecule inhibitors of fungal growth from marine and aquatic micro-organisms is also available. My lab at the University of Miami is fully equipped for yeast genetics, biochemistry, cell biology, including state of the art fluorescence imaging capability. For recent interests and publications, check the following web site: http://chroma.med.miami.edu/pharm/faculty_Lemmon.html. Interested applicants should send curriculum vita, three letters of reference and a brief description of research interests to:
Dr. Sandra K. Lemmon, Associate Professor, Dept. of Molecular and Cellular Pharmacology, University of Miami School of Medicine, P.O. Box 016189, Miami, FL 33101. Email address: slemmon@miami.edu. The University of Miami School of Medicine is an Equal Opportunity/Affirmative Action Employer.
Posted: January 22, 2006
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Research Staff
If you have a research staff opening that you would like to have posted on this page, please contact Sara Pizano (spizano@med.miami.edu or 305-243-3419)
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