Huanliang Liu , M.D., Ph.D.

Research Assistant Professor of Microbiology and Immunology
Room 736 (office) / 708 (lab), Batchelor Children's Research Institute
1580 NW 10th Avenue
Office: 305-243-1638
Fax: 305-243-7211
hliu@med.miami.edu

Research Interests:

Host genetics related to HIV and other infectious and chronic non-infectious diseases

Selected Publications:

Zhang J, Zhang X, Fu J, Bi Z, Arheart K, Barreiro L, Quintana-Murci L, Pahwa S, and Liu H. Protective role of DC-SIGN (CD209) neck-region alleles with less than 5 repeat units in HIV-1 transmission. J. Infect. Dis. in press, 2008.

Kolber MA, Saenz MO, Tanner TJ, Arheart KL, Pahwa S, and Liu H. Intensification of a suppressive HAART regimen increases CD4 counts and decreases CD8+ T-cell activation. Clin. Immun. 126(3), 315-321, 2008.

Louisirirotchanakul S, Sutthent R, Wasi C, Chuenchitra T, Nitayaphan S, Brown AE, Polonis VR, Nakayama EE, Shioda T, Liu H, and Takebe Y. Host genetic analysis of HIV Type 1 subtype CRF01_AE (E)-infected Thai patients with different rates of disease progression. AIDS Res. Hum. Retroviruses. 23, 1605-1607, 2007.

Liu H*, Nakayama EE*, Theodorou I, Nagai Y, Likanonsakul S, Wasi C, Debre P, Iwamoto A, and Shioda T. Polymorphisms in CCR5 chemokine receptor gene in Japan. Intl. J. Immunogenet. 34,325-335, 2007. (*co-first author).

Desai S, Chaparro A, Liu H, Haslett P, Arheart K, Scott G, Pahwa R, and Pahwa S. Impaired CCR7 expression on plasmacytoid dendritic cells in HIV infected children on HAART with virologic failure. J. Acquir. Immune Defic. Syndr. 45, 501-507, 2007.

White L, Krishnan S, Strbo N, Liu H, Kolber MA, Lichtenheld MG, Pahwa R, and Pahwa S. Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation and proliferation in CD8 T cells of patients infected with Human Immunodeficiency Virus-1 (HIV-1). Blood. 109:3873-3880, 2007.

Liu H, Carrington M, Wang C, Lee J, Holte S, Greene B, Hladik F, Koelle DM, Wald, A, Kurosawa K, Rinaldo CR, Celum C, Detels, R, Corey L, McElrath MJ, and Zhu T. Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility. J. Infect. Dis. 193, 698-702, 2006.

Comment: Barreiro LB and Quintana-Murci L; Reply: Liu H and Zhu T. DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: from population stratification to a possible advantage of the 7/5 heterozygous genotype. J. Infect. Dis. 194, 1184-1187, 2006.

Gramberg T, Zhu T, Chaipan C, Marzi A, Liu H, Wegele A, Andrus T, Hofmann H, Pohlmann S. Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogens. Virology. 347, 354-363, 2006.

Hladik F*, Liu H*, Speelmon E, Livingston-Rosanoff D, Wilson S, Sakchalathorn P, Hwangbo Y, Greene B, Zhu T, and McElrath MJ. Combined effect of CCR5-Δ32 heterozygosity and CCR5 promoter polymorphism −2459 A/G on CCR5 expression and resistance to HIV-1 transmission. J. Virol. 79, 11677-11684, 2005. (*co-first author).

Liu H*, Hladik F*, Andrus T, Sakchalathorn P, Lentz G, Fialkow MF, Corey L, McElrath MJ, and Zhu T. Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms. Eur. J. Hum. Genet. 6, 707-715, 2005. (*co-first author).

Liu H*, Hwangbo Y*, Holte S, Lee J, Wang C, Kaupp N, Zhu H, Celum C, Corey L, McElrath MJ, and Zhu T. Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1. J. Infect. Dis. 190, 1055-1058, 2004. (*co-first author).

Zhu T, Hu S-L, Feng F, Polacino P, Liu H, Hwangbo Y, Learn GH, Mullins JI, and Corey L. Persistence of low levels of simian immunodeficiency virus in macaques that were transiently viremic by conventional testing. Virology. 323, 208-219, 2004.

Louisirirotchanakul S, Liu H, Roongpisuthipong A, Nakayama EE, Takebe Y, Shioda T, and Wasi C. Genetic analysis of HIV-1 discordant couples in Thailand: association of CCR2-64I homozygosity with HIV-1-negative status. J Acquir Immune Defic S yndr. 29, 314-315, 2002.

Shioda T, Nakayama EE, Tanaka Y, Xin X, Liu H, Kawana-Tachikawa A, Kato A, Sakai Y, Nagai Y, and Iwamoto A. Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5. J. Virol. 75, 3462-3468, 2001.

Xin X, Nakamira K, Liu H, Nakayama EE, Goto M, Nagai Y, Kitamura Y, Shioda T, and Iwamoto A. Novel polymorphisms in human macrophage inflammatory protein-1 alpha (MIP-1α) gene. Genes and Immunity. 2, 156-158, 2001.

Nakayama EE, Hoshino Y, Xin X, Liu H, Goto M, Watanabe N, Taguchi H, Hitani A, Kawana-Tachikawa A, Fukushima M, Yamada K, Sugiura W, Oka SI, Ajisawa A, Sato H, Takebe Y, Nakamura T, Nagai Y, Iwamoto A, Shioda T. Polymorphism in the interleukin-4 promoter affects acquisition of human immunodeficiency virus type 1 syncytium-inducing phenotype. J Virol. 74, 5452-5459, 2000.

Liu H, Chao D, Nakayama EE, Taguchi H, Goto M, Xin X, Takamatsu J, Saito H, Ishikawa Y, Akaza T, Juji T, Takebe Y, Ohishi T, Fukutake K, Maruyama Y, Yashiki S, Sonoda S, Nakamura T, Nagai Y, Iwamoto A, and Shioda T. Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression. Proc. Natl. Acad. Sci. USA. 96, 4581-4585, 1999.

Liu H, Shioda T, Nagai Y, Iwamoto A, Wasi C, Ma J, Liang W, Takebe Y, Theodorou I, Magierowska M, Krishnamoorty R, Chaventre A, French ALT and IMMUNOCO Study Groups, and Debre P. Distribution of HIV-1 disease modifying regulated on activation normal T cell expressed and secreted haplotypes in Asian, African and Caucasian individuals. AIDS. 13, 2602-2603, 1999.

Shioda T, Kato H, Ohnishi Y, Tashiro K, Ikagawa M, Nakayama EE, Hu H, Kato A, Sakai Y, Liu H, Honjo T, Nomoto A, Iwamoto A, Morimoto C, and Nagai Y. Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage. Proc. Natl. Acad. Sci. USA. 95, 6331-6336, 1998.

Book Chapters:

Liu H and Zhu T. Determination of DC-SIGN and DC-SIGNR repeat region variations. Retrovirus Protocol, Virology and Molecular Biology, Methods in Molecular Biology/Molecular Medicine, Humana Press Inc. Totowa, NJ. p471-482, 2005.