"We study the developmental regulation of the immune system in a pediatric murine model. Our studies focus on cytokine production, inflammation, infectious diseases, epigenetics, and both the systemic and intestinal immune systems."

"Our laboratory is interested in understanding mechanisms of innate immunity to viral infection and malignant disease. Gaining insight into mechanisms of the innate immune process affords the opportunity of developing translational research programs involving the design of novel vaccines and therapeutics, to combat disease."

"Computer-aided drug design, small molecule modulators of the costimulatory protein-protein interaction, immunomodulation for islet transplantation"

"We focus on identification and characterization of anti-host proteins secreted by the obligate intracellular pathogen Chlamydia trachomatis. Specifically, we are interested in how these protiens modulate eukaryotic cell biology and host immune responses."

Cancer immunotherapy. Immune modulation using oligonucleotide aptamer-targeted delivery of therapeutic agents, aptamers, siRNAs, cytotoxic drugs, to tumor cells or immune cells.

"The research in the laboratory focuses on the study of: (1) molecular pathways that regulate self-renewal, activation and differentiation of hematopoietic stem cells and progenitors, (2) molecular pathways supporting self-renewal and differentiation of cancer stem cells, and (3) stem cell transformation and leukemogenesis."

Immunology of islet transplantation in pre-clinical models and in clinical subjects; immunology of clinical type 1 diabetes.

We are interested in understanding how T lymphocytes: a) control the process of hematopoietic progenitor cell engraftment following marrow / blood transplantation and b) mediate anti-tumor immunity against malignancies in individuals post-transplant.

We are interested in the signals and mechanisms of gene regulation that are critical for killer lymphocytes to defeat pathogens.

We study basic mechanisms controlling T lymphocyte development and function as they relate to autoimmunity, tumor immunotherapy, and immune memory.

The primary focus of our research is the use of cellular therapies to repair diseased tissues and organs. We are exploring conditions for in vitro generation of cellular products for use in patients.

Our lab uses the atomic force microscope to measure forces involved in biological processes, such as the adhesive events that occur during cell migration or during cell-cell interactions. Force measurements are also employed to elaborate on the energetics of vesicle fusion.

"My laboratory focuses on several key aspects of CNS injury repair: 1) preventing progressive tissue damage following the initial mechanical trauma through the application of pharmacological or biological neuroprotectants, 2) overcoming the physical impediment of the injury cyst through the implantation of exogenous cells or by harnessing endogenous cellular repair mechanisms and, 3) the promotion of axon regeneration by the stimulation of intracellular signaling pathways that are important in the initiation and/or maintainence of axon growth."

"The research in the Riley laboratory focuses upon the molecular and cellular regulation of B lymphocyte development. In particular, the processes that down-regulate immune functions in old age and other conditions of immunodeficiency are under study."

Genetic and cellular based analysis of microbial virulence factor activity.

"My research interests pertain to the role of the innate immune system, particularly of macrophages/monocytes, in the immune suppression observed in mice bearing advanced tumors. Peritoneal and tumor-associated macrophages and their precursors, monocytes in the circulation, represent and exhibit different levels of local and systemic immune suppression in the host. We have found that transcripition factors NFkB, STAT1 and STAT3 are differentially expressed in these cells, resulting in altered cell signaling pathways and cytokine gene expression patterns."